5 Steps to prevent Heart Disease

Wednesday, April 22, 2015

At Columbia Obesity Board review in NYC

Rosenbaum lecture on failure to maintain weight loss


I had a great day today listening to Mike Rosenbaum and R. Liedel at Columbia Obesity Board review.

Carb intake in 3 trials- compliance with Atkins?
One trial with weight loss drugs.
All had regain in weight after 6-9 months? I am not sure that was true of ATOZ trial.

Mike Rosenbaum said the Sachs trial NEJM 2008 kept the low carb arm to Atkins levels of 50g/d?  I found them to creep up to 175 g/d of carb, not being very different from the low fat arm?
He showed  study with Foster from Annals 2010 and at Foster, Wadden trial I found "A low-carbohydrate diet, which consisted of limited carbohydrate intake (20 g/d for 3 months) in the form of low-glycemic index vegetables with unrestricted consumption of fat and protein.
After 3 months, participants in the low-carbohydrate diet group increased their carbohydrate intake (5 g/d per wk) until a stable and desired weight was achieved"
ATOZ maintained < 50g for 12 months.

Rosenbaum’s point was that neg energy balance in humans can only be maintained for 6-9 months.  Wt. regain then starts due to Leptin reset in reduced obese.?

Rosenbaum also used  graph with wt loss drugs from Wadden NEJM 2005.  Again showing wt. regain with all drugs after about 20 weeks due to Leptin reset in reduced obese?

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