5 Steps to prevent Heart Disease

Monday, April 20, 2015

Can Gary Taubes still keep it simple?

Can Gary Taubes still keep it simple?


My comments in purple.

I am all in favor of simplicity.  That is difficult in Biochemistry.  I have culled significant quotes from a 2014 Biochemistry textbook that my son is using now in medical school.  People like to say Doctors are not taught nutrition, but this textbook is full of nutrition science.  
I have coined the term:
to try to simplify what has become a very complex science of the reduced obese.  
I think Mr. Taubes might compare this textbook to the endocrinology text he quoted in 2001.  I think the validity of LCHF has come a long way since 2001 and I think the quotes below support that.  Remember, for people with metabolic syndrome or DM2, I think it is clear that #LCHF diet is the way to go.  American Diabetic Association is slowly getting there.

Taubes pg 463 in afterword of Good Calories Bad Calories

From 2001 textbook, Endocrinology:An Integrated Approach to Endocrinology “The overall action of Insulin on the adipocyte is to stimulate fat storage and inhibit mobilization.’

Taubes goes on to say:

“With that physiologic fact as a given, any explanation for obesity or the obesity epidemic that looks beyond the influence of carbohydrates on insulin is one that is willfully trying to complicate an explanation when a simple one might suffice.”


p307-8 Ferrier text:

“Insulin is the most important hormone coordinating the use of fuels by tissues.  It’s metabolic effects are anabolic, favoring, for example, synthesis of:
1-glycogen
2-triacylglycerols (TAGs) {also known as triglycerides}
3-protein


p 309
“Ingestion of a carbohydrate-rich meal leads to a rise in blood glucose,  the primary stimulus for insulin secretion.”

p 311
“Adipose tissue responds rapidly to a rise in insulin, which causes a significant reduction in the release of fatty acids by inhibiting the the activity of hormone-sensitive lipase, which degrades lipids in adipose tissue.”

“Insulin also increases the transport and metabolism of glucose into adipocytes, providing the glycerol 3-phosphate substrate for TAG (triglyceride) synthesis.”

p 316
“Postprandial hypoglycemia is the second most common form of hypoglycemia.  It is cause by the exaggerated insulin release following a meal... causing mild adrenergic symptoms… The only treatment required is that the patient eat frequent small meals rather than the usual three large meals.”

p 325
“Circulating insulin levels are elevated in the absorptive state, resulting in an influx of glucose into adipocytes via insulin-sensitive GLUT-4 recruited to the cell surface from intracellular vesicles.

p 326
“in the fed state, elevated levels of glucose and insulin favor storage of TAG (triglycerides)”

p 366
“There is no direct evidence that the consumption of simple sugars is harmful….except dental caries.”

p 366
“Carbohydrates are not essential nutrients, because the carbon skeletons of most amino acids can be converted into glucose… The RDA for carbohydrate is set at 130 g/d for adults and children based on the amount of glucose used by carbohydrate-dependent tissues, such as the brain and erythrocytes.”

p 366
“The clinical importance of the glycemic index is unresolved,
but the evidence suggests that a low-glycemic index diet improves glycemic control in diabetic individuals.
 Foods with a low glycemic index tends create a sense of satiety over a longer period of time and may be helpful in limiting caloric intake.”

p 356
“Virtually all diets that limit particular groups of foods or macronutrients lead to short-term weight loss.  Long term maintenance of weight loss is difficult to achieve.”

We are still waiting for the evidence of long-term weight loss from #LCHF

The largest and most successful weight loss trial was LOOK AHEAD.

The research arm in the LOOK AHEAD trial was on
a low fat diet <30 fat="" nbsp="" span="">
and < 10-15% saturated fat.

However, Orlistat was used in the treatment arm and not the control arm.  see Orlistat in LOOK AHEAD

I have been on LCHF or Atkins diets since 1/2011.  My data here

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