2012 Meta-analysis link
Need to look at overall mortality- Statins good for this link to original letter and rebuttal
I respect Uffe Ravnskov and his recent letter about colon-cancer contained an impressive list of random controlled trials.
I include in this blog the authors rebuttal to Ravnskov but I felt I could look up the specific trials and find out what the total mortality was. Cancer cachexia will have low LDLc. Suicides also occur. This is why it is important to look at total mortality. 4S trial and HPS did this.
4S trial results
"The Scandinavian Simvastatin Survival Study (4S trial) randomized 4444 patients with acute coronary syndromes to simvastatin versus placebo. All-cause mortality, fatal coronary events and coronary revascularization procedures were reduced in the simvastatin group. This was regardless of the baseline HDL or LDL cholesterol levels."
HPS on wiki
"The number needed to treat in the study was 57 patients to postpone one death and 19 to prevent one cardiovascular "event" (in those taking the drug simvastatin for 5 years). There was no mortality benefit in women. Cancer risk was suggestively lower in the treatment group. No worsening of lung disease was found, an initial concern with statin drugs, and simvastatin did not decrease osteoporosis."
Statins have been given to millions of people since 1987. To my knowledge there is no association of a surge of cancer?
Ravnskov states the lower the LDLc the more the chance of cancer. In JUPITER, LDLc were as low as 35 to 55 but no increased mortality.