5 Steps to prevent Heart Disease

Thursday, October 15, 2015

The Lean eat 1 million calories a year without gaining weight

The Lean maintain their weight 
because
 their brain 
listens to 
their small intestine.

slide from Jeffrey Sicat OMA lecture
This is where the new diet medicines help the reduced obese maintain their weight loss and help the obese lose weight.

"The action of insulin on the 
REWARD PATHWAY DOPAMINERIC  neurons is thought to additionally contribute to development of obesity, since signaling of these higher neuronal circuits can override hypothalamic signaling.

Wang et al. have proposed that reward-driven overconsumption of high-fat, high sugar and energy dense foods leads to neuronal insulin resistance, dysregulation of dopamine homeostasis, and hypodopaminergic reward deficiency syndrome. "

Quoted paragraph from page 7 of 
The Clinican's Guide to the Treatment of Obesity 
Adrienne Youdim Editor








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