I paid $550 today to take the National Lipid Association Lipid Academy Course.
The first lecture is given by Dr. James Underwood.
Here are some quotes highlighted in red.
"Atherosclerosis is a single pathological process that may begin in-utero."
"The process of atherosclerosis does require the deposition of lipoprotein particles in the endothelial space to start the process."
"The first step is still unclear and is a duality of processes:
Whether the increase in the number of apo B causes the endothelial dysfunction or
the endothelial dysfunction allows the increased infiltration of apoB lipoprotein is still unclear."
I read this with surprise.
My understanding is that the main mechanism of apoB particles infiltrating the endothelial space is the concentration gradient of the particles. A high concentration gradient outside the space causes the apoB particles to enter the space. In a similar way a low level caused by statins can cause regression of the particles from the space?