Article by John Murphy
"In mouse experiments, they determined that 3-HIB is secreted from muscle cells and activates cells in the vascular wall to transport more fat into skeletal muscle tissue.
This leads to fat accumulation in the muscle that, in turn, leads to insulin resistance in mice.
Conversely, when the researchers inhibited the synthesis of 3-HIB in muscle cells, it blocked the uptake of fat in muscle.
“In this study, we showed a new mechanism to explain how 3-HIB, by regulating the transport of fatty acids in and out of muscle, links the breakdown of branched-chain amino acids with fatty acid accumulation, showing how increased amino acid flux can cause diabetes,” Dr. Arany said.
The team also found that 3-HIB is elevated in people with type 2 diabetes."