Who has healthiest hearts in the world?
Very interesting but there is still some heart disease in the tribe. 25% in elderly. Thus is this age, inflammation (age) or genetics with high cholesterol?There are silver bullets for early atherosclerosis and the sooner it is treated with multiple drugs the less chance of a cardiac event.
1-NEJM 2017 PCSK9 drug Rx
"At 48 weeks in the evolocumab group, the LDL cholesterol level was
1-70 mg per deciliter (1.8 mmol per liter) or lower in 87% of the patients,
2-to 40 mg per deciliter (1.0 mmol per liter) or lower in 67% of the patients,
3-and to 25 mg per deciliter (0.65 mmol per liter) or lower in 42% of the patients,
as compared with 18%, 0.5%, and less than 0.1%, respectively, of the patients in the placebo group (P<0 .001="" all="" br="" comparisons="" evolocumab="" for="" of="" placebo="" vs.="">
<0 .001="" all="" br="" comparisons="" evolocumab="" for="" of="" placebo="" vs.="">2-Tracy has a LDLc of 17
"At a time when the target for low-density lipoprotein (LDL) cholesterol, more commonly called 'bad cholesterol', in Americans' blood is less than 100 milligrams per decilitre (a level many people fail to achieve), Tracy's level is just 14."
3-IMPROVE IT trial for Zetia0>
Conclusions"1-When added to statin therapy, ezetimibe ( resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes.
2-Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit."
This chart above shows it took 7 years to get a good result with Zetia combo.
The Niacin combo trial was stopped after 3 years AIM HIGH TRIAL.
AIM HIGH trial stopped after only 3 years. If AIM HIGH was allowed to go on for 7 years as above IMPROVE trial did, I suspect AIM HIGH would have had similar good results .
LDLc went below 65 on combo Rx.
It is a shame this trial was stopped early due to side-effects that later turned out to be insignificant.While reports of Egyptian mummies and Amazon tribe and elderly Japanese women are interesting they are not hard science.