5 Steps to prevent Heart Disease

Friday, March 24, 2017

Who has healthiest hearts in the World?

 Who has healthiest hearts in the world?
Very interesting but there is still some heart disease in the tribe. 25% in elderly.  Thus is this age, inflammation (age) or genetics with high cholesterol?
There are silver bullets for early atherosclerosis and the sooner it is treated with multiple drugs the less chance of a cardiac event.

One thing is clear, the lower the LDLc or LDLp or apoB the less cardiac events occur.
I think the drug company paid a billion dollars on PCSK9 trial.



1-NEJM 2017 PCSK9 drug Rx

"At 48 weeks in the evolocumab group, the LDL cholesterol level was
reduced to 
1-70 mg per deciliter (1.8 mmol per liter) or lower in 87% of the patients,
2-to 40 mg per deciliter (1.0 mmol per liter) or lower in 67% of the patients,
3-and to 25 mg per deciliter (0.65 mmol per liter) or lower in 42% of the patients,

as compared with 18%, 0.5%, and less than 0.1%, respectively, of the patients in the placebo group (P<0 .001="" all="" br="" comparisons="" evolocumab="" for="" of="" placebo="" vs.="">
 
<0 .001="" all="" br="" comparisons="" evolocumab="" for="" of="" placebo="" vs.="">2-Tracy has a LDLc of 17

"At a time when the target for low-density lipoprotein (LDL) cholesterol, more commonly called 'bad cholesterol', in Americans' blood is less than 100 milligrams per decilitre (a level many people fail to achieve), Tracy's level is just 14."

3-IMPROVE IT trial for Zetia

Conclusions

"1-When added to statin therapy, ezetimibe ( resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes.
2-Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit."



This chart above shows it took 7 years to get a good result with Zetia combo.
The Niacin  combo trial was stopped after 3 years AIM HIGH TRIAL.






This chart shows results of many trials lowering LDLc. The lower the result the better the outcome.

AIM HIGH trial stopped after only 3 years.  If AIM HIGH  was allowed to go on for 7 years as above IMPROVE trial did, I suspect AIM HIGH would have had similar good results .
LDLc went below 65 on combo Rx.



​This is Terry Jacobson's slide at the Master NLA program last year.
It is a shame this trial was stopped early due to side-effects that later turned out to be insignificant.


While reports of Egyptian mummies and Amazon tribe and elderly Japanese women are interesting they are not hard science.

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