5 Steps to prevent Heart Disease

Thursday, April 12, 2018

Ketosis helps weight loss and increases appetite by increasing Adiponectin

 Article written in an easier format to understand
link above
Summary of abstract below.

My readers were surprised to read about the evidence that ketosis leads to increased adiponectin which leads to increased appetite.

I found another article that complicates the subject further.
The role of leptin/adiponectin ratio in metabolic syndrome and diabetes  link is slow

DOI 10.1515/hmbci-2013-0053      Horm Mol Biol Clin Invest 2014; 18(1): 37–45

Quote from abstract:

"Leptin/adiponectin imbalance was associated with increased waist circumference and
a decreased vascular response to acetylcholine and increased vasoconstriction due to angiotensin II.
Leptin and adiponectin have opposite effects on subclinical inflammation and insulin resistance.
Leptin upregulates proinflammatory cytokines such as tumor necrosis factor-α and interleukin-6;
these are associated with insulin resistance and type 2 diabetes mellitus.
In contrast, adiponectin has anti-inflammatory properties and downregulates the expression
and release of a number of proinflammatory immune mediators.

Therefore, it appears that interactions between angiotensin II and leptin/adiponectin im
may be important mediators of the elevated risk of developing
type 2 diabetes mellitus and cardiovascular diseases associated with abdominal obesity."
My comment;
High Leptin in obese causes leptin resistance as it should decrease hunger.
Low Leptin in reduced obese causes tremendous hunger.
Visceral obesity causes low adiponectin with increased hunger? and insulin resistance.
In ketosis apparently the increase in Adiponectin can increase hunger as you lose weight according to above the chart above.

I believe this is why the reduced obese lose the hunger abating effect (anorexigenic) of ketosis in the long run. Low Leptin eventually trumps nutritional ketosis and high protein satiating effect in 5-10 years.

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