My response to this criticism of my claim that I answered @DaveKeto lipid challenge.
I don't think I said a LDLc of 105 caused atheroma. I said high HDLc and low TG did not protect from atheroma. I said since these patients developed atheroma they need to get their LDLc down to 70. A better biomarker is non-HDLc which was 116 which is surprising considering how high the HDLc was. This number needs to get down below 80 with statin. Remember Tim Russert died with LDLc 68 but non-HDL was 118 despite aggressive treatment. Thus these people developed CAD with non-HDLc 116, trials have shown that getting their non-HDLc less than 80 will prevent many future events. I am not trying to prove the certainty of the Germ Theory as Koch did. I am trying to save lives with what has been proven to work in a convergence of evidence including the best level of evidence: large trials powered to show better mortality in double blinded random control trials.
Gearoid writes he have evidence that LDLc not correlated with CAC. I ask you to show me those studies. First, we know LDLc is a poor biomarker compared to non-HDLc and ApoB. Second, we know calcium score goes up with statins but it has to be adjusted with CAC volume. Using old studies that don't take this new information into account and ignoring the new studies is cherry picking.