Crestor 2017 Pleiotrophic effects
"Thanks to its non-cholesterol-lowering actions
represents a crucial tool for cardiovascular primary and secondary prevention.
Moreover, recent data highlight rosuvastatin beneficial effects in several other fields"
Pleiotrophic effects of Niacin 2016
"Moreover, niacin causes favorable changes to
the qualitative composition of lipoprotein HDL.
In addition to its pronounced hypolipidemic action,
niacin exerts many other, non-hypolipidemic effects
which favorably influence the development and progression of atherosclerosis.
These effects are dependent on activation of the specific receptor HCA2.
Recent results published by the two large clinical studies,
1- AIM-HIGH and
have led to the impugnation of niacin's role in future clinical practice.
However, due to several methodological flaws in the AIM-HIGH and HPS2-THRIVE studies, the pleiotropic effects of niacin now deserve thorough evaluation.
This review summarizes the present and possible future use of niacin in clinical practice in light of its newly recognized pleiotropic effects.
Zetia pleiotropic effects 2017
The results suggested that ezetimibe add-on to statin therapy is associated with an enhanced TNF-α-lowering effect compared with statin monotherapy.
Owing to the emerging role of TNF-α in the pathogenesis of metabolic disorders, further investigations are required to unveil the translational relevance of this TNF-α-lowering effect.
Pleiotropic effect of PCSK9 2016
Pleiotrophic effects of statins. 2005
Statins for Deep Vein Thrombosis
Statins anti-coagulant effect evidence not strong enough for indication 2017