Peter Attia podcast with Ruby Leibel PART 2 Anabolic and Catabolic effect of insulin not discussed

Insulin's paradoxical effects in lean and in obese.

  Insulin in lean non-IR & obese IR, peripheral ANABOLIC insulin

(except in uncontrolled DM w high glucose) 

central CATABOLIC Insulin (shares same brain pathway as Leptin). 

 How does IR and Leptin resistance affect central pathway?

 Leptin negates #LCHF in reduced obese in terms of decreasing appetite. 

Catabolic effect of Insulin and Leptin link

 "Based on all of this evidence, we hypothesized that insulin and leptin act in concert in the CNS 

to regulate caloric intake and expenditure."