Evidence not strong for fatty acids causing inflammation
Modulation of obesity-induced inflammation by dietary fats: mechanisms and clinical evidence
Nutrition Journal 2014, 13:12
doi:10.1186/1475-2891-13-12
Published: 29 January 2014
Published: 29 January 2014
Abstract (provisional)
Obesity plays a pivotal role in the development of low-grade inflammation.
Dietary
fatty acids are important modulators of inflammatory responses.
Saturated fatty acids
(SFA) and n-6 polyunsaturated fatty acids (PUFA) have been reported to exert pro-inflammatory
effects.
n-3 PUFA in particular, possess anti-inflammatory properties.
Numerous clinical
studies have been conducted over decades to investigate the impact of dietary fatty
acids on inflammatory response in obese individuals, however the findings remained
uncertain.
High fat meals have been reported to increase pro-inflammatory responses,
however there is limited evidence to support the role of individual dietary fatty
acids in a postprandial state.
Evidence in chronic studies is contradictory, the effects
of individual dietary fatty acids deserves further attention.
Weight loss rather than
n-3 PUFA supplementation may play a more prominent role in alleviating low grade inflammation.
In this context, the present review provides an update on the mechanistic insight
and the influence of dietary fats on low grade inflammation, based on clinical evidence
from acute and chronic clinical studies in obese and overweight individuals.
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