"Indeed, Miller et al have shown that the total errors for
direct HDL-C in abnormal specimens were −19.8% to 36.3% and
for direct LDL-C −26.6% to 31.9%.4
Moreover, there is evidence that directly measured LDL-C is not a more accurate measure of cardiovascular risk than calculated LDL-C.5
What then justifies the additional cost of direct LDL-C?"
the reference standard for apoB falls short of absolute perfection.3
For full letter to editor go to: Sniderman's letter to editior link