Chapter Eight
February 13, 2021
March 12, 2021
I have done well over the last 6 weeks on Ashwagandha.
It was a big step away from traditional medicine to take this step with Dr Bredesen’s Recode.
I do believe I am calmer with it and my sleep is deeper.
Yesterday I met with my Atma Doctor and asked what medicine I should take next. I suggested alpha Lipoic acid and he agreed. I purchased some on the internet today.
My Atma doctor liked my strategy with Omega 3 oils.
He already knew that Krill oil has smaller doses of DHA but by taking 3,000 mg of Lovaza I will still get good doses. The reason to take Krill oil is to get the DHA in my blood (which is at a good level) past the blood brain barrier .
. 2019 Aug 9;9(8):356. doi: 10.3390/biom9080356.
Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
Bahare Salehi 1, Yakup Berkay Yılmaz 2, Gizem Antika 2, Tugba Boyunegmez Tumer 3, Mohamad Fawzi Mahomoodally 4, Devina Lobine 4, Muhammad Akram 5, Muhammad Riaz 6, Esra Capanoglu 7, Farukh Sharopov 8, Natália Martins 9 10, William C Cho 11, Javad Sharifi-Rad 12
Affiliations expand
Free PMC article
Abstract
α-lipoic acid (ALA, thioctic acid) has various properties, among them great antioxidant potential and is widely for diabetic polyneuropathy-associated pain and paresthesia.
Naturally, ALA is located in mitochondria, where it is used as a cofactor for pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase complexes.
Despite its various potentials, ALA therapeutic efficacy is relatively low due to its pharmacokinetic profile.
Data suggests that ALA has a short half-life and bioavailability (about 30%) triggered by its hepatic degradation, reduced solubility as well as instability in the stomach. However, the use of various innovative formulations has greatly improved ALA bioavailability.
The R enantiomer of ALA shows better pharmacokinetic parameters, including increased bioavailability as compared to its S enantiomer.
To understand how this works or looks, imagine that a clock and a pole. ... Because the 4th highest priority atom is placed in the back, the arrow should appear like it is going across the face of a clock. If it is going clockwise, then it is an R-enantiomer; If it is going counterclockwise, it is an S-enantiomer.
Indeed, the use of amphiphilic matrices has capability to improve ALA bioavailability and intestinal absorption. Also, ALA's liquid formulations are associated with greater plasma concentration and bioavailability as compared to its solidified dosage form.
Thus, improved formulations can increase both ALA absorption and bioavailability, leading to a raise in therapeutic efficacy.
Interestingly, ALA bioavailability will be dependent on age, while no difference has been found for gender.
The present review aims to provide an updated on studies from preclinical to clinical trials assessing ALA's usages in diabetic patients with neuropathy, obesity, central nervous system-related diseases and abnormalities in pregnancy.
I am willing to try several other drugs advised in ReCode but slowly so that if I have a side effect I know which drug caused it or if I have benefit from it.
I think Ashwagandha has helped me not get so angry.
My mood seems more mild and my sleep is better or deeper sleep.
As I reviewed page 234 of the End of Alzheimers I was surprised to find Dr. Bredensen advises taking Ashwaganda twice a day with meals. The bottle doesn't say that so I didin't. I did notice some reflux at bed time when I take Ashwagandha, Melatonin and 4 capsules of Magnesium Threonate. I avoid the reflux by waiting a minute between each pill and more water.
On page 234 there three other drugs I was never taught about in medical school.
1- Curcumin 1 gram twice a day (or Tumeric) On empty stomach or with good fats.
2- Bacopa Monnieri 250 to 500 mg twice per day
3- Gotu kola 500 mg once or twice a day. For alertnest and focus.
Alpha Lipoic Acid 100 mg once a day advised for insulin resistance, high glucose or A1c greater than 5.5 all of which I have.
