Friday, October 23, 2015

Ghrelin was hot in 2002, Bile Acid is hot in 2014

Ghrelin levels after Gastric Bypass Surgery are low for 6-9 mos?

The bottom line shows the very low level of Ghrelin post Gastric Bypass Surgery. 
The middle line is matched obese controls who have lower Ghrelin levels than non-obese.
The top line are the non-obese controls with the highest levels of Ghrelin. 
INTERESTINGLY THE OBESE HAVE LOWER GHRELIN BECAUSE THEY HAVE HIGHER LEPTIN THAN NON-OBESE.

HOWEVER IN 2014 THE REST OF THE STORY IS BILE ACID:
2- FXR IS A MOLECULAR TARGET FOR THE EFFECTS OF VERTICAL SLEEVE GASTRECTOMY  NATURE 13135 RYAN ET AL.
3- BILE DIVERSION TO THE DISTAL SMALL INTESTINE HAS COMPARABLE  METABOLIC EFFECTS TO BARIATRIC SURGERY NATURE COMMUNICATIONS8715 FLYNN ET AL








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