Best Head to Head Trial ? Shai NEJM 2008

2 yr trial n=322 

Results: 

Low Carb High Fat in Blue:  Best increase HDLc.  
                                                 Best decrease in triglycerides. 
                                                 Best TC/HDL ratio change.

Med diet in Orange: Best decrease LDLc

Low Fat in Red: Has the worse results in biomarkers

"a. Low-carbohydrate and Mediterranean diets had greater weight loss than low-fat.

b. Lipid profile improved the best in the low-carbohydrate diet.

c. The inflammatory marker increased CRP decreased by more than 20% only in the low-carbohydrate diet and Mediterranean diet.

d. Only the Mediterranean diet decreased plasma glucose levels in a subgroup of diabetics."

N Engl J Med 2008;359:229–41

Dubnov-Raz& Berry p. 941 and p. 942

Obesity

LeRoith and Karnieli

Medical Clinics of North America

September 2011, volume 95, number 5


Another good head to head trial discussed by Dr. Vasselli video