5 Steps to prevent Heart Disease

Monday, October 19, 2015

Best Head to Head Trial ? Shai NEJM 2008

2 yr trial n=322 


Low Carb High Fat in Blue:  Best increase HDLc.  
                                                 Best decrease in triglycerides. 
                                                 Best TC/HDL ratio change.

Med diet in Orange: Best decrease LDLc

Low Fat in Red: Has the worse results in biomarkers

"a. Low-carbohydrate and Mediterranean diets had greater weight loss than low-fat.
b. Lipid profile improved the best in the low-carbohydrate diet.
c. The inflammatory marker increased CRP decreased by more than 20% only in the low-carbohydrate diet and Mediterranean diet.
d. Only the Mediterranean diet decreased plasma glucose levels in a subgroup of diabetics."
N Engl J Med 2008;359:229–41
Dubnov-Raz& Berry p. 941 and p. 942
LeRoith and Karnieli
Medical Clinics of North America

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