My contributions to science of Lipids and Obesity

My 4 original ideas as found in my four books. 

ONE: 

"Multiplier effect" is a term I coined for treatment to prevent

 cardiovascular disease in patients

 with at least one risk factor & positive CAC.

I advise treating early with multiple drugs 

(low dose statin, Endur-acin, Zetia).

Hence the term:  Multiplier Effect. 

 Low cost Low side effects.

 Resultant LDLc almost as low as PCSK9's achieve. 

TWO:

Non-HDL cholesterol was not calculated for poor Tim Russert.  

His physician was complacent with target of LDLc less than 70 achieved.  

If my term "The Tubby Factor" was used rather than

 the complex mixture of words non HDL cholesterol, 

more patients and Doctors would know it how to calculate it. 

 (Total cholesterol minus HDLc= Tubby Factor) 

Easy to remember name.  

THREE:

The Sponge Syndrome theory and term I coined to explain 

why the Reduced Obese usually regain weight. 

It's that fat cells never die

 (if they do they are replaced even with liposuction).  

Obese (BMI greater than 30) have billions of extra fats cells (adipocytes).  

When a person loses a large amount of weight

 (even with Bariatric surgery)

 they slowly regain weight 

because the billion of shrunken fats cause LOW LEPTIN LEVELS

 and all the billions of fat cells send out MiRNAs

 to the cells of the body telling the cells

 the body is starving and  to slow down metabolism.  

It's the number of fat cells that count in the Reduced Obese. 

 Not exercise.  

 Reduced Obese will regain weight even with low calorie counts

 because fat cells get priority with the extra calories
to make more fat for long term survival.  

Thus as long as the leptin level is low
 the MiRNA's are sent out

 to tell the body's cells to use the extra calories

 not to make heat but to make fat
the Reduced Obese will regain weight. 

This why it is called the Sponge Syndrome.  

All those billions of shrunken fat cells act like a sponge to make more fat. 

FOUR

Topeka Treatment for high cholesterol, low HDLc and high Triglyceride. 

Use 3 very inexpensive medications in low doses to achieve goal LDLc.

Atorvastatin 10mg
Enduracin (nicotinic acid) 1,000 mg 
Zetia (start with one half tab)

Start with one drug each month and monitor LDLc.