Chapter Eight
February 13, 2021
March 12, 2021
I have done well over the last 6 weeks on Ashwagandha.
It was a big step away from traditional medicine to take this step with Dr Bredesen’s Recode.
I do believe I am calmer with it and my sleep is deeper.
Yesterday I met with my Atma Doctor and asked what medicine I should take next. I suggested alpha Lipoic acid and he agreed. I purchased some on the internet today.
My Atma doctor liked my strategy with Omega 3 oils.
He already knew that Krill oil has smaller doses of DHA but by taking 3,000 mg of Lovaza I will still get good doses. The reason to take Krill oil is to get the DHA in my blood (which is at a good level) past the blood brain barrier .
. 2019 Aug 9;9(8):356. doi: 10.3390/biom9080356.
Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
Bahare Salehi 1, Yakup Berkay Yılmaz 2, Gizem Antika 2, Tugba Boyunegmez Tumer 3, Mohamad Fawzi Mahomoodally 4, Devina Lobine 4, Muhammad Akram 5, Muhammad Riaz 6, Esra Capanoglu 7, Farukh Sharopov 8, Natália Martins 9 10, William C Cho 11, Javad Sharifi-Rad 12
Affiliations expand
PMID: 31405030
PMCID: PMC6723188
DOI: 10.3390/biom9080356
Free PMC article
Abstract
α-lipoic acid (ALA, thioctic acid) has various properties, among them great antioxidant potential and is widely for diabetic polyneuropathy-associated pain and paresthesia.
Naturally, ALA is located in mitochondria, where it is used as a cofactor for pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase complexes.
Despite its various potentials, ALA therapeutic efficacy is relatively low due to its pharmacokinetic profile.
Data suggests that ALA has a short half-life and bioavailability (about 30%) triggered by its hepatic degradation, reduced solubility as well as instability in the stomach. However, the use of various innovative formulations has greatly improved ALA bioavailability.
The R enantiomer of ALA shows better pharmacokinetic parameters, including increased bioavailability as compared to its S enantiomer.
To understand how this works or looks, imagine that a clock and a pole. ... Because the 4th highest priority atom is placed in the back, the arrow should appear like it is going across the face of a clock. If it is going clockwise, then it is an R-enantiomer; If it is going counterclockwise, it is an S-enantiomer.
Indeed, the use of amphiphilic matrices has capability to improve ALA bioavailability and intestinal absorption.
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