Sunday, August 30, 2020

I went out shopping on my own

 I didn't drive all summer because I wife doesn't want me  to drive her car.

Now that I have my car in Topeka, I usually take a short drive in my Outbacker to keep the battery going and to remember how to drive for quick chores.


Yesterday I did the pick up at Sams and Hyvee on my own as my wife did not feel well enough to go. 


The curbside pick up routine at both Hyvee and Sams is complicated and twice we have had difficulty.  


This time I seemed to have the procedure down cold and aced it. 

Do House Flies bite

During the Covid 19 epidemic we meet with two couples weekly.

Only two at a time, outdoors, no masks but sitting 6 feet apart with two fans blowing.  They bring their own wine. 


My wife doesn't allow me to talk about politics to friends.

We still found a topic to argue about.  House Flies.

There were some flies around the table and our friend complained she were getting bitten by them.

I said house flies don't bite. 

The other 3 people from Kansas around the table insisted that they do.

I agreed that Horse Flies bite.  They agreed with that also.

They were insistent I was wrong about House Flies. 

I looked it up on google and showed them they were wrong

House flies don't have the type of mouths that bite.

Only the female Horse fly has a mouth with the ability to bite even to the point of drawing blood.

Since I have Alzheimers it is important for me to get some things right. 

Later they were saying some other nonsense about something and I told them they no longer have any credibility. 





  










 





Sunday, August 16, 2020

Lockdown #10 Some of this may be true



This article was written May 29.
Today is Aug16
By todays numbers they were so wrong in their conclusions below



 

Lockdown # 9 is written in Hebrew.

 This article is written in Hebrew, I believe


This is ridiculous. 

Ivor gave me a data dump of articles against lockdown.


He never thought I would fact check. 

If he read the articles he probably wouldn't have included them.

When I began my review I asked him to prioritize the top 3 articles.  He ignored my request. 

Is Ivor an honest broker of information? 









Lockdown #8 It is in German

This article that Ivor posted to show me overwhelming data against Covid19 lock downs is in German. 

                                                 LOL


https://www.dropbox.com/sh/zg89tdgzkqnk2ep/AACZl8CE6oL1IWG2VuYOQAUea?dl=0&preview=7.+LOCKDOWN+ADDED+LITTLE+OR+NOTHING+GERMAN+KOCH+R0+to+1+before+lockdown.pdf


Erläuterung zu den verwendeten DatenEs besteht ein großes Interesse daran das aktuelle Infektionsgeschehen und die zeitnahe Entwicklung von SARS-CoV-2-Infektionen und Covid-19-Erkran-kungsfällen in Deutschland darzustellen und zu verstehen. Naturgemäß kann niemand die tatsäch-liche Anzahl der heute oder in der vergangenen Wo-che erfolgten Infektionen genau wissen oder be-stimmen. Erst wenn die betroffenen Personen posi-tiv getestet wurden, kann deren Anzahl in einem Erhebungssystem erfasst und analysiert werden.


Lock down #7 Israel

It's too easy to show how this article Ivor choose is no longer relevant





Lockdown #6 Summary

 



I did not see anything stating conclusively that shut downs do not work

Lockdown # 5 England and Wales

 Discussion

This paper does not prove that the peak in fatal infections in England and Wales preceded lockdown by several days.

 Indeed the failure to undertake the sampling that could have gathered data to directly measure infections early in the epidemic means that it will never be possible to be certain about timings, 

given the severe biases in clinical data other than deaths and fatal disease duration. 

What the results show is that,

 in the absence of strong assumptions, the currently most reliable data strongly suggest that the decline in infections in England and Wales began before lockdown.

 Furthermore, such a scenario would be consistent with the infection profile in Sweden, which began its decline in fatal infections shortly after the UK, but did so on the basis of measures well short of lockdown.

This is wrong, the Swedes instituted a comprehensive program of restrictions that 8/10 Swedes followed at the beginning of the epidemic. True the were not lock downs.

These facts have implications for the policies to be adopted in the coming autumn, particularly given the peculiar ethical issues associated with lockdown. 

For example, plausible estimates of the life loss burden from an unmitigated COVID-19 epidemic in the UK are about 2 weeks per person1.

 A plausible lower bound on the UK life loss from the 2008 financial crisis and its aftermath is 7 weeks per person2.

The economic shock from lockdown is substantially larger than 2008. 

I disagree, the USA was late on following guidelines.  Lockdown did help but reopening was too quick.  Now we will have a much worse economic depression as Lock down will have to be re-instituted.


Similarly the implied willingness to pay to save a life year from COVID-19 appears to be an order of magnitude higher than the usual UKNational Institute for Health and Care Excellence threshold used for any other disease

Unbelievable, putting a price on life.  

Who are these people?



Lockdown # 4


Again an old article from May that was not PEER REVIEWED

Abstract

The current epidemic of COVID-19 is unparalleled in recent history as are the social distancing interventions that have led to a significant halt on the economic and social life of so many countries.

 However, there is very little empirical evidence about which social distancing measures have the most impact. 

We report a quasi-experimental study of the impact of various interventions for control of the outbreak.

 Data on case numbers and deaths were taken from the daily published figures by the European Centre for Disease Control and dates of initiation of various control strategies from the Institute of Health Metrics and Evaluation website and published sources. 

Our primary analyses were modelled in R using Bayesian generalised additive mixed models (GAMM). 

We found that closure of education facilities, prohibiting mass gatherings and closure of some non-essential businesses were associated with reduced incidence 

whereas stay at home orders, closure of all non-businesses and requiring the wearing of facemasks or coverings in public was not associated with any independent additional impact. Our results could help inform strategies for lockdown


Discussion


We have undertaken a quasi-experimental study of the impact of various forms of social distancing interventions on the epidemics of COVID-19 infection in 30 different European countries. 

Our analyses confirm that the imposition of non-pharmaceutical control measures have been effective in controlling epidemics in each country. 

However, we were unable to demonstrate a strong impact from every intervention.

 Closure of educational facilities, banning mass gatherings and early closure of some but not necessarily all commercial businesses were all associated with reduction of the spread of infection. 

Widespread closure of all non-essential businesses and stay at home orders seem not to have had much if any value.

 The results on face coverings are too preliminary to be reliable but what results are available do not support their widespread use in the community.

 Spatiotemporal hierarchical models, like the one presented here, have the advantage of being able to explicitly quantify the probability that an epidemic may or may not occur at a specific time or location. 

We have previously used similar models to account for spatiotemporal effects in health outcomes.11

Public health officials may be more inclined to deploy interventions if the probability of an epidemic exceeds a certain value.

 Ideally, public health decision-makers should agree on the specific epidemic thresholds (i.e. the incidence above which the disease requires imposition of control measures) to make model predictions meaningful. 

Whether or not school closures are likely to have been important in controlling the spread of epidemic disease is an issue of some debate in both the scientific and lay media. 

There has been uncertainty about how beneficial the closing of educational establishments can be on respiratory disease transmission 12-14. The value of school closures is particularly uncertain for COVID-19 given the observation that children have only mild or no symptoms 15

Decline in the infectiousness of the SARS-1 outbreak in Hong Kong in 2003 was also a time when many interventions were implemented, including school closures 16, making it hard to disentangle contributions of each individual measure. 

In the current pandemic, Hong Kong managed to substantially reduce the transmissibility of COVID-19 fairly early in the outbreak by a limited number of interventions one of which was keeping schools closed 17.

 However, there were also substantial behavioural change in the population at the time coincident with these interventions. 

Viner and colleagues state “Data from the SARS outbreak in mainland China, Hong Kong, and Singapore suggest that school closures did not contribute to the control of the epidemic”.

 However, this is not a valid argument against school closures as peak shedding of virus in SARS-CoV was around day 10 whereas peak shedding of SARS-CoV-2 is much earlier and possibly before symptoms develop 18-20.

 In contrast to COVID-19, SARS was primarily infectious after onset of symptoms when most cases would have been hospitalised or at least quarantined.

 Throat swabs from children have shown similar viral load to those in adults21, yet a review of contact tracing studies failed to find incidents where transmission occurred from children to adults 21

This is the problem of Ivor cherry picking old articles

Here is current information





We cannot resolve the lack of consensus in these lines of evidence, about whether children can pass SARS-COV-2 to adults.

 What our study also does not do is identify which level of school closure has the most benefit whether it is primary, junior, senior school or even higher education. 

This will need to be the focus of further research.

 Note that the results presented here are based on total closure.

 It is possible that partial school closures such as three-day weekends could have worthwhile impacts on the spread of infection 22.

 The second greatest impact on the epidemiology of the European COVID-19 was from banning mass gatherings (which could be of any size), both public and private gatherings. 

A 2018 review of the impact of mass gatherings on outbreaks of infectious disease 23 found that most evidence was linked to the Islamic Hajj pilgrimage, where most infections were respiratory, mainly rhinovirus, human coronaviruses and influenza A virus. 

The evidence for outbreaks arising from other mass gatherings such as music festivals or sporting events is less established, but not absent. 

Several outbreaks of respiratory infectious disease have been linked to open air festivals and other music festivals 23, 24

For instance, during the 2009 influenza season pandemic influenza A(H1N1)pdm09 outbreaks were recorded at three of Europe’s six largest music festivals, while some 40% of pandemic flu cases that season in Serbia were linked with the Exit music festival.

 The link with business closures is particularly interesting. 

The two variables relating to business closures are when the first closures occurred and when all non-essential closures were enforced. 

For many countries but not all, these two events occurred at the same time.

 So, there may be substantial collinearity which would underestimate the impact of one or both. 

Nevertheless, it is worthy of note that the strongest association was with the initial closures. 

Given that those initial closures were mostly directed at business where people congregate (i.e. the hospitality industry), this would suggest that these businesses are where the most impact may be had.

 Although outbreaks of food poisoning are frequently linked with restaurants, outbreaks of respiratory infections are much more rarely so. 

One exception was an outbreak of SARS at a restaurant where live palm civets were caged close to customer seating 25

Our findings on facemasks or coverings are perhaps counterintuitive especially given the strong debate on their use. 

In a recent systematic review we concluded that the evidence in favour of face mask use outside of hospital was weak.26

On the other hand a recent modelling study concluded that community facemask use could reduce the spread of COVID-19.27

Our results on face coverings should be considered to be preliminary because the use of coverings was recommended or required only relatively late in the epidemics in each European country. The results for face covering are too preliminary to inform policy but indicates that face covering as an intervention merits close monitoring


Limitations

We acknowledge that lack of direct observation of these variations may have biased our results.





Lockdown #3 German analysis




Again UK controlled its Covid19 epidemic with 12 weeks of lockdown.

 

Again Ivor sites an old article from May.

It makes a blaring mistake saying Sweden has lower deaths per capita.  Not true.

While Sweden did not do lock down, it had a rigorous Covid19 prevention program that was followed early in the epidemic by 8 of 10 Swedes.  Great compliance. 

Still Sweden has more deaths per capita than USA



Saturday, August 15, 2020

LA times on Mark Levitt

 JOE MOZINGOSTAFF WRITER 

Michael Levitt, a Nobel laureate and Stanford biophysicist, began analyzing the number of COVID-19 cases worldwide in January and correctly calculated that China would get through the worst of its coronavirus outbreak long before many health experts had predicted.

Can we rely on China data?

Now he foresees a similar outcome in the United States and the rest of the world.

While many epidemiologists are warning of months, or even years, of massive social disruption and millions of deaths, Levitt says the data simply don’t support such a dire scenario — especially in areas where reasonable social distancing measures are in place.

But as of Aug 15 there is massive social disruption and there has been million of deaths

“What we need is to control the panic,” he said. In the grand scheme, “we’re going to be fine.”

I think in USA we passed PANIC a long time ago.

Here’s what Levitt noticed in China: On Jan. 31, the country had 46 new deaths due to the novel coronavirus, compared with 42 new deaths the day before.

Although the number of daily deaths had increased, the rate of that increase had begun to ease off. In his view, the fact that new cases were being identified at a slower rate was more telling than the number of new cases itself. It was an early sign that the trajectory of the outbreak had shifted.

Think of the outbreak as a car racing down an open highway, he said. Although the car is still gaining speed, it’s not accelerating as rapidly as before. 

“This suggests that the rate of increase in the number of deaths will slow down even more over the next week,” Levitt wrote in a report he sent to friends Feb. 1 that was widely shared on Chinese social media. And soon, he predicted, the number of deaths would be decreasing every day. 

Three weeks later, Levitt told the China Daily News that the virus’ rate of growth had peaked. He predicted that the total number of confirmed COVID-19 cases in China would end up around 80,000, with about 3,250 deaths. 

This forecast turned out to be remarkably accurate: As of March 16, China had counted a total of 80,298 cases and 3,245 deaths — in a nation of nearly 1.4 billion people where roughly 10 million die every year. The number of newly diagnosed patients has dropped to around 25 a day, with no cases of community spread reported since Wednesday.

China data not reliable.

Now Levitt, who received the 2013 Nobel Prize in chemistry for developing complex models of chemical systems, is seeing similar turning points in other nations, even those that did not instill the draconian isolation measures that China did. 

He analyzed data from 78 countries that reported more than 50 newcases of COVID-19 every day and sees “signs of recovery” in many of them. He’s not focusing on the total number ofcases in a country, but on the number of new cases identified every day — and, especially, on the change in that number from one day to the next.

“Numbers are still noisy, but there are clear signs of slowed growth.”

I DON'T THINK THIS HAVE PROVED TO BE TRUE IN USA

In South Korea, for example, newly confirmed cases are being added to the country’s total each day, but the daily tally has dropped in recent weeks, remaining below 200. That suggests the outbreak there may be winding down.

In Iran, the number of newly confirmed COVID-19 cases per day remained relatively flat last week, going from 1,053 last Monday to 1,028 on Sunday. Although that’s still a lot of new cases, Levitt said, the pattern suggests the outbreak there “is past the halfway mark.”


South Korea is one of the few success stories

South Korea crushed huge virus outbreak without lockdown, but a second wave could be trickier

https://theprint.in/world/south-korea-crushed-huge-virus-outbreak-without-lockdown-but-a-second-wave-could-be-trickier/440796/

Italy, on the other hand, looks like it’s still on the upswing. In that country, the number of newly confirmed cases increased on most days this past week. 

In places that have managed to recover from an initial outbreak, officials must still contend with the fact that the coronavirus may return. China is now fighting to stop new waves of infection coming in from places where the virus is spreading out of control. Other countries are bound to face the same problem. 

Levitt acknowledges that his figures are messy and that the official case counts in many areas are too low because testing is spotty. But even with incomplete data, “a consistent decline means there’s some factor at work that is not just noise in the numbers,” he said. 

In other words, as long as the reasons for the inaccurate case counts remain the same, it’s still useful to compare them from one day to the next.

The trajectory of deaths backs up his findings, he said, since it follows the same basic trends as the new confirmed cases. So do data from outbreaks in confined environments, such as the one on the Diamond Princess cruise ship. Out of 3,711 people on board, 712 were infected, and eight died. 

This unintended experiment in coronavirus spread will help researchers estimate the number of fatalities that would occur in a fully infected population, Levitt said. For instance, the Diamond Princess data allowed him to estimate that being exposed to the new coronavirus doubles a person’s risk of dying in the next two months. Most people have an extremely low risk of death in a two-month period, so that risk remains extremely low even when doubled.

Nicholas Reich, a biostatistician at the University of Massachusetts Amherst, said the analysis was thought-provoking, if nothing else.

“Time will tell if Levitt’s predictions are correct,” Reich said. “I do think that having a wide diversity of experts bringing their perspectives to the table will help decision-makers navigate the very tricky decisions they will be facing in the upcoming weeks and months.”

Levitt said he’s in sync with those calling for strong measures to fight the outbreak. The social-distancing mandates are critical — particularly the ban on large gatherings — because the virus is so new that the population has no immunity to it, and a vaccine is still many months away. “This is not the time to go out drinking with your buddies,” he said.

Getting vaccinated against the flu is important, too, because a coronavirus outbreak that strikes in the middle of a flu epidemic is much more likely to overwhelm hospitals and increases the odds that the coronavirus goes undetected. This was probably a factor in Italy, a country with a strong anti-vaccine movement, he said.

But he also blames the media for causing unnecessary panic by focusing on the relentless increase in the cumulative number of cases and spotlighting celebrities who contract the virus. By contrast, the flu has sickened 36 million Americans since September and killed an estimated 22,000, according to the CDC, but those deaths are largely unreported. 

Levitt fears the public health measures that have shut down large swaths of the economy could cause their own health catastrophe, as lost jobs lead to poverty and hopelessness. Time and again, researchers have seen that suicide rates go up when the economy spirals down.

The virus can grow exponentially only when it is undetected and no one is acting to control it, Levitt said. That’s what happened in South Korea last month, when it ripped through a closed-off cult that refused to report the illness. 

“People need to be considered heroes for announcing they have this virus,” he said.

The goal needs to be better early detection — not just through testing but perhaps with body-temperature surveillance, which China is implementing — and immediate social isolation. 

While the COVID-19 fatality rate appears to be significantly higher than that of the flu, Levitt says it is, quite simply put, “not the end of the world.”

“The real situation is not as nearly as terrible as they make it out to be,” he said.

Dr. Loren Miller, a physician and infectious diseases researcher at the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, said it’s premature to draw any conclusions — either rosy or bleak — about the course the pandemic will take.

“There’s a lot of uncertainty right now,” he said. “In China they nipped it in the bud in the nick of time. In the U.S. we might have, or we might not have. We just don’t know.”



update trials of Alzheimers

 The best part of the day is when I have a bowel movement.   Recently started Miralax. I found MOM too harsh. Pacing helps but I get exhaust...