Gabor Erdosi April 4, 2018 on fat cells interviewed by Ivor Cummings.
9 minute segment of the total interview
go to 17 min 5 sec to 22 min 30 sec
17 min 15 sec to 17 min 52 sec
Ivor: "What drives the adipose tissue wheel "(of Obesity)
Gabor: "Thats a interesting question and I don't believe I have a clear cut answer."
Ivor: "What!"
18 mi 00 sec to 18 min 57 sec
Gabor: "you add new fat cells continuously.. some people can add basically infinite new fat cells even in adults. Typically new fat cells are added in childhood and adolescence but some people can add new fat cells later on but some people don't have any cap on this. So they can become extremely obese and still they add new fat cells that are always insulin sensitive and these new insulin sensitive fat cells keep saving them from metabolic disease."
19 min 00 sec to 21 min 4 seconds.
Ivor: "because the keep expanding, I think that is called hyperplasia.
Gabor: Yes- exactly. Yes thats hyperplasia and when the opposite happens and you are not able to add new fat cells thats called hypertrophy - so your existing fat cells ballon up and when these fat cells reach a certain size, something like 100 microns, or in this range then they become dysfunctional, mechanically, simply mechanically. So you don't need anything fancy to make a fat cell insulin resistant, You just need too much fat. {oversized fat cells}. All cells have a supporting network called cytoskeleton, basically the internal skeleton of the cell and just imagine that a huge fat droplet keeps growing in the cell and disrupts the cytoskeleton, and how insulin works in the fat cells it signals to the cells to recruit more glucose receptors , more glucose transporters [GLUT] to the cell membrane and then these transporters are being moved from internal membrane (cellular) pools to the cell membrane and even though this is not very important quantitatively - I mean fat cells only take up only 5% of glucose in the body, but its extremely important from a signaling perspective. So thats where the body's insulin sensitivity lies - in the core of the body's insulin sensitivity is that this process is working properly so you can recruit these GLUT 4 transporters to the cell membrane of fat cells and when fat gets disrupted in the cytoskeleton within the fat cell it mechanistically blocks the recruitment of the glucose transporters from the internal pool to the cell membrane {surface}.
My comments in purple:
After this Gabor gets into the importance of the cytokines from the fat cell in the signaling process. He never mentions leptin. He earlier only made a passing reference to adiponectin but not in this segment.
I wish he covered the low leptin state of the reduced obese causes weight re-gain, which is my main area of interest.
He affirms that hyperplasia of fat cells occurs in adults. The IR problem starts with the hypertrophy of those cells he says. No mention of leptin resistance unfortunately.
Gabor says: "some people can add basically infinite new fat cells even in adults."
As I write in The Chronic Disease of Obesity, the number of fat cells has the last word.
Dr Vasselli on adiopocytes link 1 min 40 sec.
1:40 second video of Prof Vasselli at Columbia U obesity conference 4-2015
9 minute segment of the total interview
go to 17 min 5 sec to 22 min 30 sec
17 min 15 sec to 17 min 52 sec
Ivor: "What drives the adipose tissue wheel "(of Obesity)
Gabor: "Thats a interesting question and I don't believe I have a clear cut answer."
Ivor: "What!"
18 mi 00 sec to 18 min 57 sec
Gabor: "you add new fat cells continuously.. some people can add basically infinite new fat cells even in adults. Typically new fat cells are added in childhood and adolescence but some people can add new fat cells later on but some people don't have any cap on this. So they can become extremely obese and still they add new fat cells that are always insulin sensitive and these new insulin sensitive fat cells keep saving them from metabolic disease."
19 min 00 sec to 21 min 4 seconds.
Ivor: "because the keep expanding, I think that is called hyperplasia.
Gabor: Yes- exactly. Yes thats hyperplasia and when the opposite happens and you are not able to add new fat cells thats called hypertrophy - so your existing fat cells ballon up and when these fat cells reach a certain size, something like 100 microns, or in this range then they become dysfunctional, mechanically, simply mechanically. So you don't need anything fancy to make a fat cell insulin resistant, You just need too much fat. {oversized fat cells}. All cells have a supporting network called cytoskeleton, basically the internal skeleton of the cell and just imagine that a huge fat droplet keeps growing in the cell and disrupts the cytoskeleton, and how insulin works in the fat cells it signals to the cells to recruit more glucose receptors , more glucose transporters [GLUT] to the cell membrane and then these transporters are being moved from internal membrane (cellular) pools to the cell membrane and even though this is not very important quantitatively - I mean fat cells only take up only 5% of glucose in the body, but its extremely important from a signaling perspective. So thats where the body's insulin sensitivity lies - in the core of the body's insulin sensitivity is that this process is working properly so you can recruit these GLUT 4 transporters to the cell membrane of fat cells and when fat gets disrupted in the cytoskeleton within the fat cell it mechanistically blocks the recruitment of the glucose transporters from the internal pool to the cell membrane {surface}.
My comments in purple:
After this Gabor gets into the importance of the cytokines from the fat cell in the signaling process. He never mentions leptin. He earlier only made a passing reference to adiponectin but not in this segment.
I wish he covered the low leptin state of the reduced obese causes weight re-gain, which is my main area of interest.
He affirms that hyperplasia of fat cells occurs in adults. The IR problem starts with the hypertrophy of those cells he says. No mention of leptin resistance unfortunately.
Gabor says: "some people can add basically infinite new fat cells even in adults."
As I write in The Chronic Disease of Obesity, the number of fat cells has the last word.
Dr Vasselli on adiopocytes link 1 min 40 sec.
1:40 second video of Prof Vasselli at Columbia U obesity conference 4-2015
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