PPY and other gut hormones affecting satiety

PPY link

My notes below
12-10-15 I passed the boards in 
American Board of Obesity

Diet medication trials.

Is there evidence for long term weight control with diet medications?
 The  2016 article below says there is evidence but I don't think there is any 5 year data.

1- People might be surprised to learn that the test arm of LOOK AHEAD used a diet drug  Orlistat to get their weight down in the first year of the trial. They didn't find it effective.

LOOK AHEAD did maintain weight loss but was negative trial link

2- Victoza data over 2 years.

Qsymia 


Two year data link

What I ate on Jan 1, 2020

I ate 1500 calories after 14 hour fast

I have been completely misrepresented that I think my LCHF caused my IR

 

I wrote the follow review of Dr Paul Mason's chapter in a book

I have Diabetes Mellitus type two since 1999.
I didn't start Atkins or LCHF till 2011.
It did not cause my glucose to become normal.
It did prevent me from gaining more weight.

 I wrote that Dr. Paul Mason does not know what he doesn't know because he knows nothing of my Sponge Syndrome theory which is why I doubt his patients will maintain their weight loss for more than five years.

Sponge syndrome validation link



I write this blog because of the disinformation campaign against me that follows the 4 D's the Russian's follow.

The Four D's of disinformation.  link

My tenth CIMT

I just did my tenth CIMT since Dec 2009

Jan 2, 2020 

Average CCA mean       Average CCA Max region

0.552                            0.685

My CAC increased in 2016. I may repeat it after a 5 year interval next year. 

The phenomenon of CAC increasing while on statins

 is why I think people should check their CIMTs to see if your treatment is failing. 

I am diabetic which many consider the root cause of cardiovascular disease. 

My Hgb A1c usually runs above 7.0, but my CIMT has not gotten worse.

I have taken a new path for my Alzheimers: Intermittent Fasting

I have taken a new path for my Alzheimers: 

                    Intermittent Fasting

Link to Editorial

Today: My fasting glucose was 116
My continuous glucose monitor (CGM) was 115

The CGM motivated me to stay on Intermittent Fasting (IF) as with numerous checks during the day I saw much better glucose levels. 

After six weeks I checked my Hgb A1c.  It was down two points.  This alone has made me determined to stay with IF. 

I was 214 lbs when I started IF on Nov 9, 2019
 and got down to 205 lbs on Dec 22, 2019
while went up to 215 lbs on Jan 1, 2020.
No significant holiday deviation in my diet. 
I walk 5,000 to 8,000 steps a day, rarely doing more than 10,000 steps. I do around 8 flights of stairs a day.  No weight lifting during this period. 

However while my weight changes up and down
the fat lbs has decreased from 61.8 to 57.9.

Today Jan 2, 2019 I weigh 213 lbs with 55.7 lbs.

Summary
1-Great improvement in Hgb A1c.
2-Loss in total fat.
3-The restriction of 12-15 hours of fasting was not as difficult as I thought with two cups of coffee. 

As far as the progression of my Alzheimers I hope lowering my glucose and keeping my LDLp as low as possible will make a difference. 



Loss in total fat.

More weight gain on Intermittent Fasting since Nov 9, 2019

I gained one pound since I stared Intermittent fasting.
Notice my fat pounds decreased from 61.8 lbs to 57.9 lbs 
My body water increased from 109.2 lbs to 114.9 lbs 


Overall it seems to be a better BIA profile.
My Hgb A1c dropped two points which I am more concerned about. 

Medical disinformation about LDLc is like the Russian's propaganda routine.

I watched a Meet the Press episode yesterday. 
I thought the disinformation could be confronted with the way Putin confuses the public. 
1-Dismiss the truth
2-Distort the truth
3-Distract from the truth
4-Dismay about the carriers of the truth 



link to Meet the Press

Medication compliance

Compliance article link

I am writing a chapter on Medication compliance in the Alzheimer patient today for my next book:
Alzheimer's Pursuit of Happiness YEAR THREE

I also made this cover photo: 

I have sent the manuscript of TRAVELING WITH ALZHEMIER'S YEAR TWO to the publisher last week.  I hope it will be on sale in Feb 2020

I gained weight on Intermittent fasting

I reached a low weight of 205.1 lbs on 12-22-19 on Intermittent Fasting

Today, 12-29-19 I gained 7 lbs over 7 days on Intermittent fasting.

I have only coffee and cream for breakfast and again at noon.

I try to not eat a salad or soup till 1 PM or 2 PM

My fasts easily last 14 hours.

I am in nutritional ketosis all the time. 

My Hgb A1c has improved by 2 points which is my main objective.

I walk 5,000 to 8,000 steps a day

I have not done any weight lifting. 

 I began Intermittent Fasting on Nov 9, 2019, I weighed 214.4 lbs.

Added Lipitor 5 mg to Zetia and Niacin

This is a non-fasting lab with triglycerides of 117.

Lovaza 2,000 mg/d

Zetia 10 mg 

Endur-acin 1,000 mg

Lab on October 11, 2019

I started 5 mg Lipitor (atorvastatin)  on Oct 22, 2019
added to Zetia 10 and Enduracin 1,000 mg

December 21, 2019

This is a fasting lab with  with triglycerides 50
Lovaza 4,000 mg/d

The point of this personal experiment was to show extremely low lipid levels with triple therapy
Lipitor 5,
Zetia 10 mg,
Enduracin 1,000 mg.

This should be tried with maximum dose Lipitor or the stronger Crestor before PCSK9 IV is tried.

My LDLp is >300 on Lipitor 5 mg.
I will increase my Lipitor to 10 mg/d then check my apoB (a particle level different than LDLp) level in Feb 2020.

I am doing this for my personal experiment where I want to get my apoB as low as possible for
my theory of getting apoB and LDLp as low as possible
to prevent progression of my Alzheimer's.


Effects of changing drugs over last year link

My next experiment is to stop Zetia today.
I will be taking 
Atorvastatin 10mg/d
Endur-acin 1,000 mg/d
Lovaza 4,000 mg/d







Can cholesterol be too low?  link