Thursday, February 6, 2020

Damn the Coronavirus. Full speed ahead.




Saturday, February 29

Yokohama (Tokyo), Japan



Sunday, March 1

Yokohama (Tokyo), Japan

Depart: 5:00 PM

Monday, March 2

At Sea


Tuesday, March 3

Nagasaki, Japan

Arrive: 8:00 AM Depart: 6:00 PM


Nagasaki Sights

  • 10:00 AM
  • Wednesday, March 4

    Kagoshima, Japan

    Arrive: 8:00 AM Depart: 5:00 PM

    2020030


    Panoramic Kagoshima

  • 10:00 AM
  • Booked for: 
    • Brian Edwards
    • Virginia Eaton

    Thursday, March 5

    At Sea



    Friday, March 6

    Naha, Japan

    Arrive: 7:00 AM Depart: 5:00 PM
    Buy Shore Excursions20200306


    Okinawa in Depth

  • 8:00 AM

  • Saturday, March 7

    Ishigaki Island, Japan

    Arrive: 8:00 AM Depart: 6:00 PM
    Buy Shore Excursions20200307


    Ishigaki Half Day

  • 10:00 AM
  • Booked for: 
    • Brian Edwards
    • Virginia Eaton
  • Cancel this Shore Excursion?

  • Sunday, March 8

    Keelung (Taipei), Taiwan

    Arrive: 8:00 AM
    Buy Shore Excursions20200308

    Monday, March 9

    Keelung (Taipei), Taiwan

    Depart: 4:00 PM
    Buy Shore Excursions20200309


    Taipei Highlights

  • 8:30 AM
  • Tuesday, March 10

    At Sea



    Highlights of Kaohsiung



  • Wednesday, March 11

    Aburatsu, Miyazaki, Japan

    Arrive: 10:00 AM Depart: 6:00 PM

    Thursday, March 12

    At Sea



    The Charms of Old Manila


  • Friday, March 13

    Shimizu, Japan

    Arrive: 7:00 AM Depart: 5:00 PM

    Saturday, March 14

    Yokohama (Tokyo), Japan

    Arrive: 7:00 AM

    LDLc 38 on Low Carbohydrate High Fat Diet




    How to calculate remnants

    Step one 
    TC-HDL
    111 - 59= 52 nonHDLc

    Step two
    NonHDLc - LDLc
    52-38= 14 remnants (should be less than 20?)


    I eat 60% fat on a Low Carbohydrate diet 
    with high protein. 
    I have done this since 2011.

    The lab above is on the following medications:

    1-Lipitor 10 mg/d (atorvastatin)

    2-Endur-acin (nicotinic acid) 1,000 mg/d (OTC)

    3-Lovaza 4,000 mg/d 
     I,000 mg of Lovaza contains:
    eicosapentaenoic acid (EPA - approximately 465 mg) and
     docosahexaenoic acid (DHA - approximately 375 mg).

    My triglyceride level is quite low due to all three medications. I usually do my lab non-fasting. 

    I was diagnosed with type 2 Diabetes Mellitus in 1998.



    This morning:
    Glucose 164
    Ketones 4.0






    Wednesday, February 5, 2020

    My latest lab





    I am in Florida and below are prior results with Quest lab.

    My last apoB which may be more accurate than LDLp .

    In May 2017 apoB 66 (LDLp was 1,100)
    In Jan 2020 is down to 50 (LDLp was 756)
    Does not look as if I have discordance. 







    I always found my Quest LDLp to be higher than my Lab Corp LDLp results
    Quest LDLp Jan 2020 was 756
    My Lab Corp  LDLp was 300

    I believe Quest does not use NMR and thus the LDLp numbers are not equivalent.
    Their LDLp range says less than 1,100 LDLp is optimal.

    This Quest lab in Jan 2020 was done on Lipitor 10 mg and Enduracin (nicotinic acid) 1,000 mg but off Zetia this time. 








    My Quest LDLp Jan 2020 was  on Lipitor 10 mg Niacin 1,000 mg and off Zetia.

    My Lab Corp (done by a different method NMR) was 300 on Lipitor 5, Zetia and Niacin.

    Link to NMR LDLp

    I had increased my Lipitor to 10mg because I did not want to cut those pills in half.
    I thus stopped Zetia.

    Notice my nonHDLc  is lower on higher dose of Lipitor
     Lipitor10mg off Zetia 41 vs.
    Lipitor 5 mg on Zetia.  92

    Notice my TG went up because the test with Quest was not fasting. 





    This is interesting data on Lp (a)

    May 2017 Lp(a) 79.
    Jan 2020.  Lp (a) 60

    Niacin helped? or just aggressive lowering of LDLp and app B with Triple Topeka Therapy





       This is my review of:

    Dr. Dale Bredesen's TED podcast 2-1-20 Link

    Dr. Bredesen presents two cases in his podcast that have done well on his protocol.

    Case One



    He states this patient improved with nutrients and antibiotics for a chronic undiagnosed infection. 
    In my experience as a Board certified geriatrician the first thing we checked in a confused older women was urine sample.  Bactrim resolved their confusion very quickly.  This is not Alzheimer's

    Case Two



    Dr Bredesen states Edward had
    1- low chronic inflammation
    2- low methylation
    3- low vitamin D level
    4- low prednisolone ? 

    When treated Edward improved and sustained this improvement for six years.
    Dr. Bredesen says in the podcast that this is "unheard of in Alzheimer's disease"

    My response the patient does not have Alzheimers disease.  He has reversible hormone and medical problems easily treated by conventional methods. Conventional medications would have resolved the transient confusion Edward had. 








    Dr. Bredesen wrote The End of Alzheimer's 

    I have reviewed his book in many of my blogs starting with:
     Number One review link goes over his eleven  patients below that he has posted. 


    My Amazon review of The End of Alzheimers 




    My MRI and PET/CT imaging

    In 2014 I asked my Internist Jennifer Schied if there was a Alzheimer’s trial I could enter? She didn’t know of any.

    I studied for 6 months to take the American Board of Obesity Medicine  exam on 12-10-15.
    I received notice I passed the exam on 1-28-16.
    How could I have Alzheimer’s?

    I wanted to open an obesity clinic in Topeka but the Board asked me to be evaluated before they re-activated my license. 

    Colorado Physician Evaluation Program (CPEP) 
    charged me $8,000 for the one day evaluation done in Denver at their office on August 15, 2016.





    On Jan. 26, 2017 I was asked by a neurologist,
    "What does it matter if you have Alzheimer's. There is no cure."


    MRI finding 2-3-17





    PET Amyloid scan December 2017

    This was paid for by a trial.
    Usually $5,000
    I got into the trial on the last day of availability thanks to my neurologist in Florida.
    Two weeks later I was back in Kansas and he called the result. 
    It was very sad for me to hear the news. 
    He had me start Namzaric. 






    Research MRI done at Hogland 7-17-18

    I get a repeat MRI each year for my non-treatment trial along with lab work and 3 hour cognitive testing. 
    They never did a spinal tap for CSF as I am on Xarelto blood thinner.

    I don't get to see the results anymore. 





    At KUMCR a neurology memory specialist told me I had Alzheimers
     based on my heterogeneous AZ gene positivity and my poor sequential cognitive testing. 

    He said "8% of heterozygotes go on to have Alzheimer’s.
    30% of homozygotes go on to have Alzheimer’s."


    The Doctor said I had mild cognitive impairment. 

    I wanted to learn my diagnosis of Alzheimer's as early as possible so I could put my affairs in order. 

    I also wanted to start medication as soon as possible.









    Tuesday, February 4, 2020

    Pre-interview questionnaire from Feb for Radio interview

    Letter from my Publisher with form filled out


    Upon receipt, we will forward your responses to the interviewer with TOGInet, who will contact you regarding the scheduling of your radio interview. We recommend keeping a copy of this questionnaire and having it nearby when you’re called for your interview, as this will help you make the most of your interview by conveying what you want about your book.

    1-What was the purpose of your book?
    To show patients with the diagnosis of Alzheimer’s (such as myself) that as much as the shock that the diagnosis brings there are still many years to joy to come. 


         
    2. Who does the book appeal to and why?
    Anyone who is worried about getting Alzheimers.
         
    3. What one thing do you want readers to learn/take away from this work?
    Have fun as a response to the disease. 


    4. What scenes and/or characters would you like to highlight during the interview? (Think of this part of the interview like a movie trailer. Exciting parts of your book to tease listeners. Unforgettable characters which would motivate listeners to buy your book.)
    I write the book in the first person
    which is unique for a book on Alzheimer’s. 
    I write a diary of my progress with the disease of Alzheimer’s. 
    The disease is inexorable and after the anxiety I dealt with in the first year, 
    I moved on to not worrying so much about the disease. 
    I am writing year three now.  
    People will be able to follow me during the course of my disease and 
    see that it is not as bad as it is depicted. 
         
    5. How would you introduce your book to a friend in a sentence or two? (I will use this to introduce the book at the beginning of the interview)
    What life with Alzheimer’s over a series of Years is like by writing in the first person. 
         
    6. Tell me how this book is unlike others with similar topics. What sets it apart from the crowd?
    It does not propose ways to prevent or cure Alzheimers. (no nostrums) 
    It is not gloom and doom. 
    It is not written by a caretaker affected by the disease. 
    It shows how I live life to the fullest each year despite the disease. 
    I am totally transparent about my testing to make the diagnosis of my disease. 
    In Year One I post my :
    1- two day six hour psychological testing report. (8 pages)
    2- MRI scan report
    3- PET amyloid scan
    4- Details of my visits to the KUMCR trial that I am participating in. 


    7. When and where does your story take place? [For novels -- Why did you choose this setting?
    The world. 
    I live in Florida and Kansas but we fill the books with our travels as well.
         


    8. What three words best describe this story? Its characters?
    "Honest" 
    "Personal"
    "Fun"

    Me (primary character written in first person in diary form)

         
    9. What was the most challenging part about writing this book? The most fun/rewarding?
    The most difficult part is trying to meet the required criteria of publishing the book online.
    The technical transfer of the manuscript is very challenging.
         


    10. Is there anything we haven't covered here that you feel is important for people to know about your book?
    I am a physician certified in: 
    Internal medicine, geriatrics, infectious disease, obesity and lipidology 
    and have clinical experience treating dementia patients in nursing. 
    Despite all that training I didn't know what I didn't know.
    It is often said the Alzheimer's patient doesn't suffer, the family suffers.
    I learned this is not true.
    I was taught there was loss of self. I find out the real story.
    I learned many new things about the disease which I plan
    to convey to my audience in easy language of daily experiences
    to give patients hope but not false hope
         


    By signing this form you agree all the information is correct as it pertains to your TOGInet Radio Interview.



    By signing this form you agree all the information is correct as it pertains to your TOGInet Radio Interview.


    Signature:   Brian Edwards
    Date:   2-4-20


    Disclaimer

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    Sunday, February 2, 2020

    75 pages of Alzheimer's books, none of them a personal diary over years.



    Link to Amazon's list of Alzheimers book





    My second book on my personal journey having Alzheimers diagnosis since Dec 2017 will be available for purchase by the end of this month, I hope.

    List of my yearly series of books on Alzheimers:

    I am waiting for when I forget I have Alzheimers. YEAR ONE

    Traveling with Alzheimers. YEAR TWO

    The Pursuit of Happiness with Alzheimers. YEAR THREE

    I am presently writing the YEAR THREE book.


    As I reviewed the 75 pages of books on Alzheimers
     I only found one other author who writes in the first person about having Alzheimers. 
    Defeating Alzheimers by Francis McNear
    My review of McNear book here link


    My series of books has transparency about the tests I did to determine my diagnosis.

    Most of the books on the Amazon list cover the following topics:
    1- How to prevent or cure Alzheimers with diet
    2- How to care for Alzheimers patients
    3- Brain games to improve your memory


    I don't know how my yearly series ends or how long I will be able to continue it.

    My YEAR ONE book was published one year ago in Feb 2019 was not on the Amazon list.
    Maybe when YEAR TWO comes out next month, I will be on the list.

    My YEAR ONE book is for sale on Amazon.
    My listing with Amazon link


    I then looked up Alzheimers books published in 2019 link

    I was not mentioned in this short list either.

















    Saturday, February 1, 2020

    Price reduction in Cialis has made it a part of my treatment for Alzheimers




    On October 18, 2019 I decided on a new course to treat my Alzheimers.

    link My Cure for Alzheimers

    I wrote this in response to several books claiming the end or the antidote or defeating Alzheimers.

    I reviewed them and found they had very little evidence for their claims.

    1- Review of The Antidote for Alzheimers link

    2- Review of the End of Alzheimers link

    3- Review of Defeating Alzheimers link

    Since there is no cure for Alzheimers I decided to determine the best course for myself. 



    My addition of daily low dose Viagra was a dramatic departure of what is advised. 
    Generic Viagra is still expensive. 
    I would buy 30 tablets of Sildenafil 20 mg.
    The usual dose for erectile dysfunction is 50 to 100 mg as needed per day.
    In October I started taking 20 mg a day for Alzheimers.

    This week I found I could buy full dose Cialis for about the same price.  I started generic Cialis every other day or 3 times a week. 





    Viagra for Alzheimers link


    update trials of Alzheimers

     The best part of the day is when I have a bowel movement.   Recently started Miralax. I found MOM too harsh. Pacing helps but I get exhaust...