Pregnenolone 10 mg

 Pregnenolone 10 mg is a new drug I started today 

under the orders of my Atma Holistic MD for my Alzheimers.  

One

Two

Three

Four

I have all the symptoms above. 

Now I take 10 mg a day and wait four months. 

If that doesn't work then I double the dose and see what side effects I have? 

Thanks to  Deborah Gordan M.D. for her advice and experience.

From page 132 in The End of Alzheimers 

by Dr Dale Bredesen

Clearly my DHEA level is low. 

However when I asked my endocrinologist about giving it to me he said it was not mainstream.

I will start with pregnonlonve.

I am starting new drugs for Alzheimers

 

My Atma Recode specialist now advises the 3 drugs below.

I am also interested in these drugs below. 

This is the list he also says I choose from:

This is alot of drugs. 

I try one at a time in case I have a side effect.

I alreadly take a methylated B vitamin.

Looking forward to my second cognoscopy next week to see if my B vit levels got better.

My manganese and Vit c levels were already good.

I already take many drugs and supplements. 

One way I know my Mild Cognitive Impairment or early Alzheimers is not getting alot worse is I can still keep track of taking my medications. 

Choline

 Choline link

Even if we have good levels of choline that doesn't   help AZ pateints as they have low levels of the enzymze that converts choline into Acetylcholine in the brain.

Drugs for AZ. link

Since I eat eggs and take Namzaric, I suspect this is why none of my three neurologists told me to increase my choline intake

On Atkins I was eating 3 fried eggs a day.

440 mg of choline a day.  

Males should take in 550 mg

Females should take in 450 mg. 

I had extensive nutrients levels done with Bredesen protocol COGNOSCOPY, I could not find a choline level? 

 

I happily went back to 3 eggs a day.

Can't tolerated liver. 

Omega 3 blood tests

 Recently I became concerned w getting enough DHA into my brain.

My DHA level was normal on two different tests at

 3.6 weight percentage. 

I have no idea what "weight percentage" means.

After receiving the excellent info from Dr Davidson I started Krill Oil. 

Why did I develop Alzheimers

List of risks:

 1- Mid-life hearing loss. 

I got hearing aides at age 65 yo for mild hearing loss.

 2- Failure to complete secondary education.

 I went all the way to completing an Infectious disease fellowship.

3- Failure to treat depression early

Began treating my dysphoria in my forties with Prozac

4- Smoking

I never smoked

5- Physical inactivity

I exercised my whole life. 

6- Social isolation

I didn't go out to bars but I had friends and family

7- High Blood Pressure 

I began Ramipril in 1998 when I was diagnosed with DM2

8- Obesity

I have been obese most of my life 1% risk

9- Type Two Diabetes.  2% risk

Diagnosed in 1998

10- Excessive alcohol usage. 

I only began drinking in last 10 years.

11- Tramatic Brain Injury 3.4% risk

12- Air pollution 

The total of my risk factors equals 6.4%

However was heterozygous positive for AZ gene. Add 16%?

That is a total of 20% risk.

My poor interrupted sleep over the years a physican should be considered.  

I got a CPAP in 1968. 

My uncle died from AZ,

Put all these factors together with a positive Pet Scan for Amyloid 

I recieved the diagnosis of AZ in December 2017.

"Impression: Findings are metabolically compatible with moderate to severe diffuse beta amyloid pathology involving the bilateral temporal, occipital and frontal lobes." 

Intermittent fasting is helping bring my Glucose down after ice cream.

Yesterday my glucose was 150 and ketones 1.9 at 9:00 AM after skipping breakfast at 12:05 PM after 13 hour fast Glucose was 137 and ketones 2.8 Today my glucose was 168 and ketones 2.1 at 6:53 AM After 13 hour fast my glucose went down to 155 and ketones went up to 3.1 I was doing 16 hour fasts but after a while paradoxically my glucose went up. I believe it was due to chronic stress of fasting and it raise my cortisol level. In Wiki: "Glucagon during fasting When fasting the hormone glucagon is stimulated and this increases plasma glucose levels in the body. If a patient doesn't have diabetes, their body will produce insulin to rebalance the increased glucose levels."

I just started book three of the trilogy by Peter May

 A new achievement and a new mental exercise.  

I have not been reading novels since my diagnosis of Alzheimers in Dec 2017.  

I have been obessive watching politics in preparation of the 2020 Presidential election. 

I also learned from the memory book Moon Walking with Eintstein that people don't remember the books they read? 

Truth is, I forget TV series we have watched and often need to watch the first season again to remind us of what is going on with the second season. 

It was different with this novel, Blackhouse by Peter May.

Most importantly I underlined all the names of the characters.  

In movies and TV I will often forget who the characters are talking about when they mention a name.

Easier in a book to flip pages back and find the highlighted name. 

Secondly if there are no subtitles in the movie or series, I will miss dialogue evheyen though I have my hearing aides in.  

With a book I can read the paragraph and truly understand what is going on in the conplex plot.  

How I chose this book.

Last week I was walking along Jensen Beach and I stopped to talk to a couple I had never met before. 

They said they were from Canada.  

I replied Canadians, nicest people in the world. 

The husband thanked me. 

I asked him if he know how to make a Canadian say:

"I'm sorry."

I told him you step on the Canadians toe. 

He laughed. 

He told me about a great detective novel placed in the Hebrides, Scotland.  I am planning a trip to Scotland and was interested. 

The first book of the Trilogy, Blackhouse is extremely well written.  

A little slow at first but after the first 100 pages it started to pick up.

The last 100 pages was fast and furious. 

It was a great experience for me as I highlighted many parts of it. 

Looking forward the reading the next two books in the trilogy. 

Timely subject considering the George Floyd death by Police trial.

I have watched many forensic series.  

Silent Witness is very good. 

I am also a physician but I never knew the facts below. 

Even the present trial in Minnesota does not explain 

how easy it is to strangle someone.  

I just started Peter May's book Blackhouse. 

 

My annual vist to my Florida neurologist bring good news.

 Annual visit to Florida neurologist.

March 23, 2021

I have three neurologists. 

Dr. Elliott made my diagnosis in Dec. 2017.

Dr. Swerdlow is my KUMC Research center neurologist. He entered me into my non-treatment study.  I have had three years of scans with the study but I am not told the results. 

I have a neurolgist close to home in Topeka.

Dr. Elliott gave me some good  news.  There should be an IV infusion given once a month to take away the amyloid plaques. 

I am thinking I will continue all of the ReCode medication I am already taking. 

I told Dr. Elliott about my subdural.  He was very concerned as I am on an anticoagulant.  

I told him about my festination. 

He did a foot tapping test with which I did poorly.

He then stood behind me and did a “pull test” to see how quickly recovered.  It was clear to him I was having problems similar to Parkinsonism, which I don’t have but enough neurons have been compromised by my Alzheimers to cause similar symptoms. 

He asked me to walk in the pool 30 minutes three times a week.  

This is my link to my visit last year with 

my MOCA test 

This year he didn’t do a MOCA as he felt it wasn’t sensitive enough.

I told him I have more extensive testing at KUMC Memory center.  He asked me to send me the results of those tests. 

I remember when I had a finger tapping test at one cognitive test in 2017.  I thought I had done well. The tester said 80 year old men could do better.

The Big News was a new drug coming out this June. 

Taking the next step in Dr Bredesen's ReCode protocol.

 Chapter Eight

February 13, 2021

March 12, 2021

I have done well over the last 6 weeks on Ashwagandha. 

It was a big step away from traditional medicine to take this step with Dr Bredesen’s Recode. 

I do believe I am calmer with it and my sleep is deeper. 

Yesterday I met with my Atma Doctor and asked what medicine I should take next.  I suggested alpha Lipoic acid and he agreed.  I purchased some on the internet today.  

My Atma doctor liked my strategy with Omega 3 oils.  

He already knew that Krill oil has smaller doses of DHA but by taking 3,000 mg of Lovaza I will still get good doses.  The reason to take Krill oil is to get the DHA in my blood (which is at a good level) past the blood brain barrier .  

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. 2019 Aug 9;9(8):356. doi: 10.3390/biom9080356.

Insights on the Use of α-Lipoic Acid for Therapeutic Purposes

Bahare Salehi 1, Yakup Berkay Yılmaz 2, Gizem Antika 2, Tugba Boyunegmez Tumer 3, Mohamad Fawzi Mahomoodally 4, Devina Lobine 4, Muhammad Akram 5, Muhammad Riaz 6, Esra Capanoglu 7, Farukh Sharopov 8, Natália Martins 9 10, William C Cho 11, Javad Sharifi-Rad 12

Affiliations expand

• PMID: 31405030

•  PMCID: PMC6723188

•  DOI: 10.3390/biom9080356

Free PMC article

Abstract

α-lipoic acid (ALA, thioctic acid) has various properties, among them great antioxidant potential and is widely for diabetic polyneuropathy-associated pain and paresthesia.

Naturally, ALA is located in mitochondria, where it is used as a cofactor for pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase complexes. 

Despite its various potentials, ALA therapeutic efficacy is relatively low due to its pharmacokinetic profile.

Data suggests that ALA has a short half-life and bioavailability (about 30%) triggered by its hepatic degradation, reduced solubility as well as instability in the stomach. However, the use of various innovative formulations has greatly improved ALA bioavailability.

 The R enantiomer of ALA shows better pharmacokinetic parameters, including increased bioavailability as compared to its S enantiomer. 

To understand how this works or looks, imagine that a clock and a pole. ... Because the 4th highest priority atom is placed in the back, the arrow should appear like it is going across the face of a clock. If it is going clockwise, then it is an R-enantiomer; If it is going counterclockwise, it is an S-enantiomer.

Indeed, the use of amphiphilic matrices has capability to improve ALA bioavailability and intestinal absorption. 

Also, ALA's liquid formulations are associated with greater plasma concentration and bioavailability as compared to its solidified dosage form. 

Thus, improved formulations can increase both ALA absorption and bioavailability, leading to a raise in therapeutic efficacy.

Interestingly, ALA bioavailability will be dependent on age, while no difference has been found for gender. 

The present review aims to provide an updated on studies from preclinical to clinical trials assessing ALA's usages in diabetic patients with neuropathy, obesity, central nervous system-related diseases and abnormalities in pregnancy.

I am willing to try several other drugs advised in ReCode but slowly so that if I have a side effect I know which drug caused it or if I have benefit from it.

I think Ashwagandha has helped me not get so angry.

My mood seems more mild and my sleep is better or deeper sleep.

As I reviewed page 234 of the End of Alzheimers I was surprised to find Dr. Bredensen advises taking Ashwaganda twice a day with meals. The bottle doesn't say that so I didin't. I did notice some reflux at bed time when I take Ashwagandha, Melatonin and 4 capsules of Magnesium Threonate. I avoid the reflux by waiting a minute between each pill and more water.

On page 234 there three other drugs I was never taught about in medical school.

1- Curcumin 1 gram twice a day (or Tumeric) On empty stomach or with good fats.

2- Bacopa Monnieri 250 to 500 mg twice per day

3- Gotu kola 500 mg once or twice a day. For alertnest and focus.

Alpha Lipoic Acid 100 mg once a day advised for insulin resistance, high glucose or A1c greater than 5.5 all of which I have.

My big accomplishment today

 It took two days but with the help of my wife we assembled this Keiser bike. 

We came to a standstill on the first day when we could not line up the screw holes of the fly wheel despite multiple attemtps.  

On the second day, I called the help line.  He said just line up the top hole and when you put the hub cap just don't move the fly wheel when you put the first screw in. 

I told him that is easier said than done.  This is a bad design.  The help line said he was sorry about that.  

It is difficult even for him sometimes. I said okay we will try again. 

I tried a new approach.  I put the (heavy) bike on my desk to work on it. 

I also got a flashlight.

We finally succeeded on getting the flywheel on. 

 

This was a major accomplishment for me with my Alzheimer's.  

I couldn't have done it without my wife's help. 

I was surprised how I maintained my cool and and did not get too frustrated 

while my wife was crusing like a sailor and got very angry.  

I have been taking Ashwagandha twice/day to relieve stress and improve sleep.

She is only taking one each night.  Time for her to go to 2X/day?

I got this bike after listening to Dr Issacson on Peter Attia's podcast say that 10,000 steps a day is not good enough exercise.  Dr Issacson said High Intensity Interval Training (HIIT) is crucial. 

However on Dr. Attia's recent Q and A live podcast he emphasized his ZONE TWO exercise level to get the most beneficial lactate level.  His zone requires a steady low level of exercise.  

To make certain I do the correct amount of watts, I purchased the above bike he advised.  Pricey at $1.300 but the real challenge turned out to be the home assembly.