Friday, July 30, 2021

Climbing the Bredesen ReCode supplement ladder.

"Alpha-GPC for Cognition + Benefits, Dosage & Side Effects

Written by Aleksa Ristic, MS (Pharmacy) | Reviewed by Ana Aleksic, MSc (Pharmacy) | Last updated: July 30, 2020"

"Alpha-GPC is a crucial component for the brain and a popular nootropic supplement.

It may boost mental and physical performance and supply choline to protect the nerves. Still, clinical research supports only a fraction of promoted supplementation benefits."

"Choline from alpha-GPC also builds acetylcholine, a neurotransmitter that maintains your cognitive and muscle functions "

In some European countries, alpha-GPC is a prescription drug for Alzheimer’s disease (Gliatilin, Delecit).

In the US, it’s sold as a dietary supplement for memory enhancement.

Supplement and drug manufacturers usually derive alpha-GPC from egg or soy lecithin."

"Skeptics:

May cause headaches and digestive issues
May increase irritability
Not safe for children and pregnant women"

CDP-Choline vs. Alpha-GPC

Let’s start with the basics. CDP-choline or citicoline is made of choline (with two phosphate groups) and cytidine,

while alpha-GPC is made of choline (with one phosphate group) and glycerol.

This may sound pretty similar, but it gives rise to some interesting, distinct effects in the body [8].

For one, alpha-GPC raises choline blood levels to a greater extent than CDP-choline.

As a result, it has a more powerful impact on age-related cognitive decline and physical performance.

Secondly, alpha-GPC may stimulate fat burning and growth hormone production, giving it an edge over CDP-choline among bodybuilders [9, 10, 11,12, 13].

On the other hand,

CDP-choline is essential for the production of phosphatidylcholine.

It has a broader range of active metabolites and potential benefits on mental health"

"In Alzheimer’s disease, bundles of mutated proteins kill neurons and deplete acetylcholine, causing an array of cognitive issues [28].

In a clinical trial of 260 patients, alpha-GPC improved all symptoms of Alzheimer’s disease. In another trial of 113 patients,

it boosted the effects of standard treatment (donepezil) [29, 30]."

In Alzheimer’s disease, bundles of mutated proteins kill neurons and deplete acetylcholine, causing an array of cognitive issues [28].

"In a clinical trial of 260 patients, alpha-GPC improved all symptoms of Alzheimer’s disease. In another trial of 113 patients, it boosted the effects of standard treatment (donepezil) [29, 30]."

Second article on alpha GPC link

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