Review of End of Alzheimers #9

1- Optimize diet
I have been in nutritional ketosis since 2011. 
I did this to maintain my weight loss with less hunger. 
However I eat a lot of meat.  Bredesen says to avoid meat. 

2-Enhance autophagia, ketosis
Bredesen advises fasting 12 hours a day including 3 hours before bedtime. 
I am not sure about the theory of autophagia.
But for people who can do this without too much pain I will allow it.  I just know for myself that 3 hours before sleep if the most difficult time for me to not to snack.  Too painful for me to do it 
since I am in nutritional ketosis every morning anyway.

No human trials demonstrating efficacy with Alzheimer's

3- Reduce stress.
Yoga, meditation or music.
All the above fine with me. 
I used the meditation technique from Alzheimers Association as  when I am stressed or I am trying to be patient because it is such an easy technique.  
Simply say 
Sha
Tha
Na 
Ma 
 with a finger exercise simultaneously. 
Thumb and finger shift with each word.
I think the best way to avoid stress is have fun
rather than trying to comply with such an overwhelming program such as ReCODE. 
It puts the responsibility on the patient.  Very stressful and unnecessary when there is little evidence for success. 


4- Get 7-8 hours of sleep
This is good advice especially to rule out sleep apnea. 
Not sure melatonin or tryptophan helps with sleep for all as I think it is more for circadian rhythm rather than sleep induction. 

Sleep problems can be very difficult. 
I get up 3 to 5 times a night to urinate.
Fortunately I rarely have trouble falling back asleep.
I have a memory palace where I have memorize 55 European countries.  I usually fall asleep before I get through the whole list. 

5- Exercise
I try to walk at least 5,000 steps. 
I often do not make it to 10,000 steps
Trials have shown an Alzheimer should exercise 150 minutes a week. 
20 minutes x 7 is 140 minutes. 
I usually do more than 20 minutes and I walk up steps 5-10 times a day.


 6- Brain stimulation
Not sure what this is?  Crossword puzzles or Soduka?

"The aim of this systemic review was to determine the available tests for the assessment of executive functions with ecological validity to predict individuals function."

7- Homocysteine level

I have no problem with people getting a homocysteine level. 

8- B 12 greater than 500
This included in traditional work up of dementia. 
I doubt my level is low as I eat a great deal of meat. 


9- CPR less than 1.0 
I would advise getting a hsCRP

10- Fasting insulin level more than 7 
 and Hemoglobin A1c less than 5.5

I don't think people should wait till they have memory loss.  If fasting glucose greater than 95 you probably have pre-diabetes.  Best test is 2 hour post prandial test. Best treatment is weight loss with Atkins or Low carbohydrate High fat diet. 

11- Hormone balance 
Probably good idea with Endocrinologist help. 
These labs can be confusing even to your family physician and often need to be done in a special way or timing. 
I take testosterone IM 100 mg a week since 2011 to help libido.

12- GI health

If you are concerned with this diagnosis please get confirmation confirmation from a Gastro-intestinal specialist. 




Celiac disease is not a cause of Alzheimers

13 Abeta = Amyloid

Only way to know this is to get a PET scan for Amyloid plaque

Curcumin and Ashwaganhda have no human trials decreasing Amyloid plaque

14-  Cognitive enhancement

Bacopa, Manniera and Magnesium have not be shown to improve thinking in Alzheimers patient trial.


15- Vitamin D (25OH-D3)
Get level from 50-100 ng/ml

I agree it is a good idea for the elderly to check their Vitamin D level, especially during February. 

16- increase NGF

This is interesting. Basil forebrain implants.

This mushroom is typical Chinese Herbal Medicine. 

Not enough information to advise either of these drugs. 


17- Provide synaptic structural components
Citacoline
DHA

DHA is part of the four Lovaza capsule I take
DHA 375 x 4= 1500 mg
Dr. Bredesin advises 1,000 mg a day